Blar i forfatter "Cascorbi, Ingolf"

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    • Drug-Drug-Gene Interactions: A Call for Clinical Consideration 

      Bruckmüller, Henrike; Cascorbi, Ingolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
      It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ...

    • Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells 

      Kaehler, Meike; Litterst, Merit; Kolarova, Julia; Bohm, Ruwen; Bruckmueller, Henrike; Ammerpohl, Ole; Cascorbi, Ingolf; Nagel, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-22)
      Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In the present study, in ...

    • Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters 

      Awortwe, Charles; Bruckmüller, Henrike; Kaehler, Meike; Cascorbi, Ingolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)
      Preparations of Echinacea purpurea (E. purpurea) are widely used for the management of upper respiratory infections, influenza, and common cold, often in combination with other conventional drugs. However, the potential of phytochemical constituents of E. purpurea to cause herb−drug interactions via ABCB1 and ABCG2 efflux transporters remains elusive. The purpose of this study was to investigate ...

    • The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients 

      Sachau, Juliane; Bruckmüller, Henrike; Gierthmühlen, Janne; Magerl, Walter; May, Denisa; Forstenpointner, Julia; Koetting, Judith; Maier, Christoph; Tölle, Thomas R.; Treede, Rolf-Detlef; Berthele, Achim; Caliebe, Amke; Diesch, Carolin; Flor, Herta; Huge, Volker; Maihöfner, Christian; Rehm, Stefanie; Kersebaum, Dilara; Fabig, Sophi-Charlotte; Vollert, Jan; Rolke, Roman; Stemmler, Susanne; Sommer, Claudia; Westermann, Andrea; Cascorbi, Ingolf; Baron, Ralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-10)
      <p>Background - The serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whether HTR2A single nucleotide variants (SNVs) modulate neuropathic pain states in patients has not been investigated so far. The aim of this study was to elucidate the potential ...